New doctors continue to shake up the hospital in typical Grey Sloan manner. Meredith bonds with a patient while Jackson struggles with the meaning behind recent experiences; and after making a life-changing decision, Jo forms an unexpected alliance.
Maggie reevaluates her life choices after receiving an invitation to her ex-boyfriend´s wedding; Richard questions Bailey´s loyalty, and Jo confides in Stephanie about a secret she´s been keeping from Alex. Meanwhile, Alex struggles with making a difficult decision that will affect the lives of newborn twins.
Meredith turns heads when she shows up to work done up and ready for her blind date later that day, while Alex makes a questionable decision in order to save a patient. Meanwhile, the burden of knowing Teddy´ s secret keeps Maggie up at night, ultimately making her decide she has to tell someone.
With Cristina gone, a new doctor, Maggie Pierce, making the rounds and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina´s board seat and a freak accident causes two teenagers to be caught in a very compromising position.